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WASHINGTON — Federal prosecutors indicted Democratic Sen. Robert Menendez on corruption charges on Wednesday for allegedly using his Senate office to push the business interests of a friend and donor in exchange for gifts , according to the Justice Department.

The case, brought by the Justice Department’s public integrity unit, sets up a high-stakes battle between a New Jersey senator who has fought off investigations for years, and federal prosecutors and the FBI who have spent years pursuing him.

“Robert Menendez, a U.S. senator, and Dr. Salomon Melgen, a Florida ophthalmologist, were indicted today in connection with a bribery scheme in which Menendez allegedly accepted gifts from Melgen in exchange for using the power of his Senate office to benefit Melgen’s financial and personal interests,” said Peter Carr, a Justice Department spokesman, in a statement.

The two were indicted in the district of New Jersey for one count of conspiracy, one count of violating the travel act, eight counts of bribery and three counts of honest services fraud; Menendez was also charged with one count of making false statements, according to Carr’s statement.

Federal officials and Menendez’s attorneys had discussed plans for the New Jersey Democrat to turn himself in before a planned court hearing on Thursday, according to people briefed on the case.

Menendez is expected to address reporters at 7 p.m. in Newark, New Jersey, according to his office.

“We have no way to comment on a document we have not seen,” a spokeswoman for Menendez said. “Incredibly, the Department of Justice has made clear, once again, their motives by informing the media before informing the senator.”

The government’s case, as first reported by CNN last month, centers on Menendez’s relationship with Melgen, who the senator has called a friend and political supporter. Melgen and his family have been generous donors to the senator and various committees the senator is associated with.

Investigators have focused in part on plane trips Menendez took in 2010 to the Dominican Republic as a guest of Melgen. In 2013, after word of the federal investigation became public, Menendez paid back Melgen $58,000 for the 2010 plane trips calling his failure to properly disclose the flights an “oversight.”

Menendez has said he’s innocent, noting that he has been friends with Melgen for more than 20 years and that the two families have spent holidays and other special occasions together.

After CNN reported on the pending charges, Menendez told reporters that he has “always conducted myself appropriately and in accordance with the law. And I am not going anywhere.”

One of the highest-ranking Hispanic members of Congress, Menendez is a former chairman of the Senate Foreign Relations Committee. He has become one of the Obama administration’s most vocal Democratic opponents on two key foreign policy matters — President Barack Obama’s decision to ease the trade embargo against Cuba and also his effort to engage direct negotiations with Iran over that country’s nuclear program.

Prosecutors were under pressure in part because of the statute of limitation on some of the allegations. Attorney General Eric Holder signed off on the plan to bring charges and had expected to be gone by the time they were announced. However, an unrelated political fight over abortion in the Senate has stalled the nomination of Holder’s successor, Brooklyn U.S. Attorney Loretta Lynch.

This is the first indictment of a sitting senator since the prosecution of Ted Stevens, whose conviction the Justice Department tossed out because of prosecutor misconduct in the case.

It poses a high-profile test of the Justice Department’s ability to prosecute sitting lawmakers, having already spawned a legal battle between prosecutors and Menendez’s attorneys over whether key evidence the government has gathered is protected by the Constitution’s Speech and Debate clause.